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Buck
Breakthroughs
 
Winter 2021
Chronic inflammation causes a reduction in a NAD+
Research from the Verdin lab links hallmarks of aging. Publishing in Nature Metabolism, researchers show that an increasing burden of senescent cells, which is implicated in the aging process, causes the degradation of the key metabolite NAD+, which is also linked to aging.
News
Tissue stiffness likely drives immune responses in many chronic diseases
Stiffness in our tissues causes tension in our cells. Research from the Winer lab reveals that this stiffness ups the metabolism of the innate immune system. The findings suggest the cellular tension likely sets off an inflammatory loop that contributes to the development of chronic diseases of aging, and suggests the possibility of new immunotherapeutics.
A compound that slows bone loss, and a resource for developing treatments to slow aging
A longitudinal and functional study of 700 aging mice provides a treasure trove of data for those studying aging and age-related diseases.  During the course of the research scientists identified a compound that extends lifespan in a tiny nematode worm and slows bone loss in aging mice.
The Buck appoints Malene Hansen, PhD, as Chief Scientific Officer
Malene Hansen, who comes to the Buck from the Sanford Burnham Prebys Medical Discovery Institute where she was a professor in the Development, Aging and Regeneration Program, will be responsible for providing leadership and guiding the strategic scientific direction of the Institute. She will also oversee research operations, faculty development, postdoc and student mentoring, and internal and external collaborations in support of this strategy.
Profile
Prominent gerontologist Dr. John “Jack” Rowe returns to the Buck Board of Trustees
In 1985 Dr. Rowe assembled a panel of experts to consider the creation of the Buck Institute and later testified as an expert witness at the trial which led to our establishment. The former CEO of Aetna was a founding Trustee and led our first Scientific Advisory Board when the Buck opened its doors in 1999.  Twenty-one years later the renowned gerontologist and public health expert has returned to serve again as a Buck Trustee.
From our Blog
Healing a broken heart: Time, or decreasing expression of a single protein
Absence makes the heart grow weaker, especially when it comes to declining heart muscle with age. Our new blog post outlines the potential of reducing a key protein for heart muscle cell renewal.
Buck in the News
 
 
DNA tests to pinpoint biological age
Buck CEO Eric Verdin led off an article for AARP that highlighted the use of DNA tests to pinpoint biological age – as opposed to chronological age.
 
 
Vaccinations for COVID-19 have begun!
The Buck was very proud to loan sub-zero freezers to the Marin County Health Department in order to store the life-saving vaccines at the proper temperature.
Marin Independent Journal
 
 
Buck Faculty highlighted in Marin Living Mag
Marin Living Magazine did a major story on the Buck in their January/February issue. The article highlighted research from Buck faculty Judith Campisi, Julie Andersen and Francesca Duncan, as well as entrepreneur-in-residence, Brianna Stubbs.
 
 
Love podcasts? KGNU talked to Gordon Lithgow
Boulder, CO radio KGNU took a deep dive into Buck professor Gordon Lithgow's study showing that the body-building supplement alpha-ketoglutarate dramatically compressed late-life disability in mice.
 
 
Marin Mag tackles health markers, w/ Buck’s help
Dr. Verdin talked about preventive health, genetic testing and the biomarkers of the future in an article with lots of practical advice. 
 
A conversation with our new Chief Scientific Officer
The San Francisco Business Times asks Malene Hansen about her own research and her role in pushing Buck science forward.
Upcoming Events
TBA
 
In-person events postponed until further notice
Due to COVID-19 orders that limit the size of in-person gatherings in California, all public events are cancelled until further notice.  Updates will be posted on our website as they become available.
 
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