COVID-19 and TB
Knowledge and Library Services Evidence Update
Part of the Barts Health Education Academy
Hello and welcome to this edition of Barts Health Knowledge and Library Services’ monthly COVID-19 and TB Evidence  Update.

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News and Opinion

Guidance and Institutional Publications
Latest Research Articles

Library COVID Update
New on our Website
Our Other Recent Updates

News and Opinion

Blog from BMJ Opinion: Community based interventions can help fight covid-19 and tuberculosis
"Control of TB and covid-19 does not need to be antagonistic. The care could be integrated in parallel as the risk factors, symptoms, and modes of spread of these two diseases are similar. This would require capacity building, but more importantly, strong will by policymakers and key stakeholders who can ramp up investments in such programmes... Among wealthy nations, America spends the most on healthcare, but fares worst when it comes to the perception of care. It is crucial to understand that access to care is driven by a community’s receptivity to care. Active models of care eliminate biases brought on by social inequities. Reaching out to these hotspots—the pandemic’s seismic zones—will have long-term payoffs by bridging disparities in America..." 
From [India]: Covid can make a person more susceptible to TB but no direct link between the two yet, says Centre
"The Union Health Ministry on Saturday said that coronavirus infection could make a person more susceptible to developing tuberculosis, as it was an “opportunistic infection like black fungus”, but added that there was not enough scientific evidence to link the two... The government said that reports of a sudden increase in the number of tuberculosis cases among patients recovering from Covid-19 had left doctors worried..."
From The Union: The 100th anniversary of bacille Calmette-Guérin (BCG) and the latest vaccines against COVID-19
"The vaccines against COVID-19 were developed in less than one year and have high efficacy. Nevertheless, concerns about the effectiveness of vaccination remain, as SARS-CoV-2 variants of concern continue to emerge. As we celebrate the centenary of the oldest vaccine in the world – and the success of the vaccines for COVID-19 – we must remember the features they have in common, and the ongoing need for further research to improve and develop better vaccines..."

Guidance and Institutional Publications

Recording and Materials from The National Academies of Science, Engineering and Medicine's Online Workshop of 22/7/21: Innovations for Tackling Tuberculosis in the Time of COVID-19: A Two-Part Workshop Series (Part 1)
"This public workshop is the first in a two-part series that examines the innovations needed to meet the targets for ending tuberculosis (TB) set by the World Health Organization's END TB Strategy for 2030. “Innovations for Tackling Tuberculosis in the Time of COVID-19” will feature presentations and discussions that will consider the development of affordable point-of-care tuberculosis diagnostic tests, improvements in TB care, how to utilize the existing TB platform in low-to-middle-income countries to address COVID-19 and other airborne infections in order to prevent future pandemics, and how to ensure increased and sustained commitments to reach the goal of ending TB in high burden countries despite the challenges from COVID-19..."

Latest Research Articles

Effect of BCG vaccination on proinflammatory responses in elderly individuals
"We investigated the influence of Bacillus Calmette-Guérin (BCG) vaccination on the unstimulated plasma levels of a wide panel of cytokines, chemokines, acute-phase proteins (APPs), matrix metalloproteinases (MMPs), and growth factors in a group of healthy elderly individuals (age, 60 to 80 years) at baseline (before vaccination) and 1 month after vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrated that BCG vaccination resulted in diminished plasma levels of types 1, 2, and 17 and other proinflammatory cytokines and type 1 interferons. BCG vaccination also resulted in decreased plasma levels of CC, CXC chemokines, APPs, MMPs, and growth factors. Plasma levels of the aforementioned parameters were significantly lower in vaccinated individuals when compared to unvaccinated control individuals. Thus, our study demonstrates the immunomodulatory properties of BCG vaccination and suggests its potential utility in nonspecific vaccination of COVID-19 by down-modulating pathogenic inflammatory responses..."
Coinfections with Other Respiratory Pathogens among Patients with COVID-19
"From June 2020 through January 2021, we tested 191 patients with SARS-CoV-2 for 33 other respiratory pathogens using an fast track diagnostics respiratory pathogen 33 (FTD-33) assay. Additionally, information regarding other relevant respiratory pathogens was collected by reviewing their laboratory data. Overall, 13 pathogens were identified among patients infected with SARS-CoV-2, and 46.6% (89/191) of patients had coinfection with one or more additional pathogens. Bacterial coinfections (41.4% [79/191]) were frequent, with Staphylococcus aureus being the most common, followed by Klebsiella pneumoniae. Coinfections with SARS-CoV-2 and Pneumocystis jirovecii or Legionella pneumophila were also identified. The viral coinfection rate was 7.3%, with human adenovirus and human rhinovirus being the most common. Five patients in our cohort had positive cultures for Acinetobacter baumannii and K. pneumoniae, and two patients had active Mycobacterium tuberculosis infection. In total, 47.1% (90/191) of patients with coinfections were identified..."
Coinfection of SARS-CoV-2 and MTB: how not to miss the wood for the trees
"Scarce data exist about the coinfection of SARS-CoV-2 and Mycobacterium tuberculosis (MTB). A young woman who was undergoing treatment for multiple sclerosis was brought to our hospital with a COVID-19 positive status. On further evaluation, her chest X-ray showed right upper and mid-zone opacity, which lead to the suspicion of MTB. Her sputum came positive for acid-fast bacilli (AFB) staining and cartridge-based nucleic acid amplification test (CBNAAT) confirmed it, and rifampicin resistance was not detected. She was started on an antitubercular regimen. She was discharged, and by the end of the intensive phase of treatment, her symptoms subsided, but her sputum CBNAAT still showed the presence of TB bacillus..."
Multidrug-resistant tuberculosis in COVID-19: Double trouble
"COVID-19 pandemic has changed the lives of many especially those living with chronic diseases. India has the highest burden of multidrug resistant tuberculosis (MDR TB) in the world. The pandemic and the lockdown created multiple bottlenecks in the provision of healthcare as well as the distribution of medications. The stigma of tuberculosis leads to mental trauma, suffering, delay in diagnosis, and non-compliance to therapy. Lockdown imposed due to COVID-19, aggravated the fears of each patient and had made medical care access difficult. Here we describe a patient with MDR TB and chronic hepatitis B and how the course of the disease and its management was affected by COVID-19..."
"Both humoral and cell-mediated responses are associated with immunity to SARS-CoV-2. While our understanding of the potential role of T-cell responses in the context of COVID-19 is rapidly increasing, more information is still needed.OBJECTIVES: To provide an overview of the role of T-cell immunity in COVID-19, in the context of natural infection and post-vaccination, and discuss the potential utility of measuring SARS-CoV-2-specific T-cell responses, drawing on experience of the use of interferon-γ release assays (IGRAs) in tuberculosis (TB)..."
Diagnostics and management of tuberculosis and COVID-19 in a patient with pneumothorax (clinical case)
"The spread of COVID-19 in countries with high and medium incidence of tuberculosis has led to an increased risk of COVID-19 and tuberculosis co-infection, introducing new diagnostic and therapeutic challenges for the clinician. Hereby we describe a first case where tuberculosis and COVID-19 were diagnosed concomitantly in a Russian patient with pneumothorax. We discuss the challenges associated with the diagnosis and treatment of tuberculosis during the COVID-19 pandemic..."
Effects of COVID-19 prevention procedures on other common infections: a systematic review
"PubMed, Embase, Web of Science, Scopus, Science Direct, Google Scholar, Research Gate, and the World Health Organization databases and websites were systematically searched for original studies concerning the impact of COVID-19 prevention means and measures on other common respiratory infectious diseases during the pandemic published by March 2021... The findings showed that the adherence to health protocols to prevent COVID-19 could help to reduce the incidence of other infectious diseases such as influenza, pneumonia, and Mycobacterium tuberculosis..."

Library COVID Update

All staff are now required to sign-in, and wash their hands with the gel provided, when entering our libraries.

St Bart’s Hospital Library has moved back to its original space in the department of diagnostic imaging, on the ground floor of the KGV Building. It will be staffed from 10am-4pm, Monday to Friday, and available to staff 24/7. The phone no. there is 020 3465 5467.

At Whipps Cross and Newham Hospitals we offer comfortable seats and computer access, with tea and coffee, from 10am-4pm. Please check local notices for details. Staff can continue to access our 24/7 knowledge hubs (computer rooms) on each site.

Our Library Hub at the Royal London continues to be available to staff 24/7.

Please see our new website and our Digital Library WeShare page for more information.

New on Our Website

Browse the resource collections within our COVID-19 pages; plus further services, resources, and NHS discounts have been added to our Wellbeing pages.

Our  Leadership and Management subject guide collects all our services and resources on the topic, and signposts to external help.

You can now search the entirety of our collection from the website homepage below via the Discovery search bar too...

Visit Green at Barts Health's new website, hosted and maintained by Knowledge and Library Services:


Our Other Recent Updates

Read our latest Inclusion and Diversity Update (published 29/7/21) here.
Read our latest COVID-19 Update (published 27/7/21) here.
Read our latest Delirium in Intensive Care Evidence Alert (published 16/7/21) here.
Read our lateset Emerging Technologies in Healthcare Update (published 14/7/21) here.
Read our latest Staff Wellbeing Update (published 8/7/21) here.
Read our latest Safer Surgery Update (published 7/7/21) here.
Read our latest COVID-19 and TB Update (published 5/7/21) here.
Read our round-up of research published by Barts Health authors in the month of June 2021 (published 2/7/21) here.
Read our latest monthly Leadership Update (published 1/7/21) here.
Read our latest Health Services Management Update (published 18/6/21) here.

Catch up with all our archived updates on our Digital Library Weshare page.

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