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COVID-19
Knowledge and Library Services Evidence Update
Part of the Barts Health Education Academy
13/7/21
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Hello and welcome to this edition of Barts Health Knowledge and Library Services’ monthly COVID-19 Evidence Update.

Please let us know how we can improve future updates by providing feedback, and let us know if there are any resources or publications you would like us to feature.

To find out more about the library services available to you, including our highly-regarded literature searching service and desktop document supply service, please visit our WeShar
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CONTENTS:
News and Opinion

Guidance and Institutional Publications
Latest Research Articles

Library COVID Update
Visit on our Website
Our Other Recent Updates

News and Opinion

From iNews: Lockdown easing: Sage modelling expert Graham Medley says Covid situation after 19 July is ‘unknowable’
From HSJ:
From BBC News: Long Covid: Early findings bring hope for diagnostic tests
Open letter published in The Lancet: Mass infection is not an option: we must do more to protect our young
"Signed by >120 scientists... We call on govt to pause its plans & take urgent action to protect the public Scientists/HCWs can sign here: https://johnsnowmemo.com"

Guidance and Institutional Publications

From 10 Downing Street: Prime Minister confirms move to Step 4
"Step 4 of the Roadmap to go ahead on Monday 19 July..."
From Public Health England:
Press release from The British Medical Association: Don’t wait to start public COVID-19 inquiry, says BMA – as Association begins its’ own pandemic ‘lessons learned’ review
"In the absence of an imminent start to the public inquiry into the UK’s handling of the COVID-19 pandemic, the BMA is beginning its own ‘Lessons learned’ work and will publish evidence relating to key areas of the pandemic response..."
News Story from The Department of Health and Social Care: DHSC recognises the importance of transparent face masks to make communication easier
"Since September 2020, DHSC has been working on a coordinated range of initiatives to enable the creation and availability of safe and effective transparent face masks to health and social care..."
Updated by NICE: COVID-19 rapid guideline: managing COVID-19, NICE guideline [NG191]
"On 3 June 2021 we added new recommendations on azithromycin to treat COVID-19..."
Report from The Health Foundation: Unequal pandemic, fairer recovery: The COVID-19 impact inquiry report
" This report is a comprehensive review of the factors that fuelled the UK’s Covid-19 death toll. It finds working-age adults in England’s poorest areas were almost four times more likely to die from Covid-19 than those in the wealthiest areas. The Health Foundation calls on the government to learn the lessons from the financial crisis and invest in health, to rebuild the economy and prevent long-term scarring..."

Latest Research Articles

Like soldiers on the front – a qualitative study understanding the frontline healthcare professionals’ experience of treating and caring for patients with COVID-19
"A sample of 22 frontline healthcare professionals caring for patients with COVID-19 was included and interviewed individually from May to August 2020. Ricoeur’s phenomenological hermeneutical philosophy inspired the methodology in this study..."
COVID-19 and male reproductive system: pathogenic features and possible mechanisms
"According to studies, COVID-19 occurs in severe patients as respiratory disease, along with multi-organ failure. The most important mechanisms are classified as direct and indirect pathogenesis of SARS-CoV-2. The presence of ACE2 on the cell surface of various cells in testis increases the risk of direct infection by this virus. SARS-CoV-2 also affects the testis through the cytokine storm. In addition, the important role of HPT axis dysregulation through impaired Leydig cells and hypothalamus should be considered. Using antiviral and immunomodulatory therapy can be harmful for testis function. Further investigations are required to investigate potential mechanisms of male infertility in survivals of COVID-19. Since involvement of testis is essential for fertility, increasing the knowledge of health system may improve the outcomes..."
COVID-19 and ischemic stroke
"Since the onset of the COVID-19 pandemic, a substantial proportion of COVID-19 patients had documented thrombotic complications and ischemic stroke. Several mechanisms related to immune mediated thrombosis, the renin angiotensin system, and the effect of SARS-CoV-2 in cardiac and brain tissue may contribute to the pathogenesis of ischemic stroke in patients with COVID-19. Simultaneously, significant strains on global healthcare delivery, including ischemic stroke management, have made treatment of stroke in the setting of COVID-19 particularly challenging. In this review we summarize the current knowledge on epidemiology, clinical manifestation and pathophysiology of ischemic stroke in patients with COVID-19 to bridge the gap from bench to bedside and clinical practice during the most challenging global health crisis of the last decades..."
Safety of SARS-CoV-2 vaccines: a systematic review and meta-analysis of randomized controlled trials 
"A total of 73,633 subjects from 14 articles were included to compare the risks of adverse events following immunization (AEFI) after vaccinating different COVID-19 vaccines. Pooled risk ratios (RR) of total AEFI for inactivated vaccine, viral-vectored vaccine, and mRNA vaccine were 1.34 [95% confidence interval (CI) 1.11–1.61, P < 0.001], 1.65 (95% CI 1.31–2.07, P < 0.001), and 2.01 (95% CI 1.78–2.26, P < 0.001), respectively. No significant differences on local and systemic AEFI were found between the first dose and second dose. In addition, people aged ≤ 55 years were at significantly higher risk of AEFI than people aged ≥ 56 years, with a pooled RR of 1.25 (95% CI 1.15–1.35, P < 0.001)..."
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
"Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases..."
[Preprint] Covid-19 Vaccination in Pregnancy: A Systematic Review
"Twelve observational studies with a total of 40.509 pregnant women included. The mRNA based vaccines (Pfizer-BioNTech and Moderna) can prevent future SARS-CoV-2 infections (p=0.0004). Both vaccines did not affect pregnancy, delivery, and neonatal outcomes. The most commonly encountered adverse reactions are injection-site pain, fatigue, and headache but only transient. Antibody responses were rapid after the prime dose of vaccines. After booster, antibody responses were higher and associated with better placental antibody transfer. Longer intervals between first vaccination dose and delivery were also associated with higher antibody fetal IgG and better antibody transfer ratio..."
[Preprint] Implementation, adoption and perceptions of telemental health during the COVID-19 pandemic: a systematic review
"A total of 77 papers met our inclusion criteria. In most studies, the majority of contacts could be transferred to a remote form during the pandemic, and good acceptability to service users and clinicians tended to be reported, at least where the alternative to remote contacts was interrupting care. However, a range of impediments to dealing optimal care by this means were also identified..."
[Preprint] A systematic review of persistent symptoms and residual abnormal functioning following acute COVID-19: Ongoing symptomatic phase vs. post-COVID-19 syndrome
"Of the 1,145 studies screened, 39 were included, all describing adult cohorts with long COVID and sample sizes ranging from 32 to 1,733. Studies included data pertaining to symptomatology, pulmonary functioning, chest imaging, cognitive functioning, psychological disorder, and/or quality of life. Fatigue presented as the most prevalent symptom during both OSC and PCS at 43% and 44%, respectively. Sleep disorder (36%; 33%), dyspnoea (31%; 40%), and cough (26%; 22%) followed in prevalence. Abnormal spirometry (FEV1 <80% predicted) was observed in 15% and 11%, and abnormal chest imaging observed in 34% and 28%, respectively..."
[Preprint] Transmissibility of COVID-19 among Vaccinated Individuals: A Rapid Literature Review - Update #1
"In this update, 16 additional studies, including 9 human and 7 animal studies, were included. Therefore, this review examines a total of 33 included studies: 21 human studies and 12 preclinical animal studies. Evidence from two large household surveillance studies from the UK suggests that a single or full dose of AstraZeneca (AZ) and Pfizer-BioNtech (PfBnT) vaccines may prevent household transmission of COVID-19 after 14 days of vaccination by up to 54%..."
[Preprint] Neurological, neuropsychiatric and psychiatric symptoms during COVID-19 infection and after recovery: a systematic review of observational studies
"The most frequently reported neurological symptoms were ageusia, hyposmia/anosmia, dizziness, headache, and loss of consciousness. Statistically significant relationships were noted between Asian ethnicity and peripheral neuropathy (p=0.0001) and neuro-syndromic symptoms (p=0.001). ITU admission was found to have a statistically significant relationship with male sex (p=0.024). Depression and anxiety were also identified both during and after infection. The most frequent treatments used were intravenous immunoglobulins, followed by antibiotics, antivirals, and hydroxychloroquine; with mean treatment duration of 6 days..."
 

Library COVID Update

All staff are now required to sign-in, and wash their hands with the gel provided, when entering our libraries.

St Bart’s Hospital Library has moved back to its original space in the department of diagnostic imaging, on the ground floor of the KGV Building. It will be staffed from 10am-4pm, Monday to Friday, and available to staff 24/7. The phone no. there is 020 3465 5467.

At Whipps Cross and Newham Hospitals we offer comfortable seats and computer access, with tea and coffee, from 10am-4pm. Please check local notices for details. Staff can continue to access our 24/7 knowledge hubs (computer rooms) on each site.

Our Library Hub at the Royal London continues to be available to staff 24/7.

Please see our new website and our Digital Library WeShare page for more information.
 

Visit Our Website

Browse the resource collections within our COVID-19 pages for cross-skilling and critical care information; plus further services, resources, and NHS discounts have been added to our Wellbeing pages.

Our  Leadership and Management subject guide collects all our services and resources on the topic, and signposts to external help.

You can now search the entirety of our collection from the website homepage below via the Discovery search bar too...
 

Visit Green at Barts Health's new website, hosted and maintained by Knowledge and Library Services:
 

 

Our Other Recent Updates

Read our latest Staff Wellbeing Update (published 8/7/21) here.
Read our latest Safer Surgery Update (published 7/7/21) here.
Read our latest COVID-19 and TB Update (published 5/7/21) here.
Read our round-up of research published by Barts Health authors in the month of June 2021 (published 2/7/21) here.
Read our latest monthly Leadership Update (published 1/7/21) here.
Read our latest Inclusion and Diversity Update (published 30/6/21) here.
Read our previous COVID-19 Update (published 29/6/21) here.
Read our latest Health Services Management Update (published 18/6/21) here.
Read our latest monthly Delirium in ICU Evidence Alert (published 17/5/21) here.

Catch up with all our archived updates on our Digital Library Weshare page.
 

Happy to help.

If you require the full text of any of the articles mentioned above, or any other assistance, please email bartshealth.library@nhs.net

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