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Ontario Neurodegenerative disease research initiative
 
The ONDRI Insider
May 2019
WELCOME TO THE FIRST QUARTERLY EDITION OF THE ONDRI INSIDER

Our goal is to keep you informed about ONDRI research, collaborations, news and events.

In the first phase of ONDRI, we built a solid foundation. We enrolled 520 participants, and collected millions of data points on each participant. Thank you to our team for your contributions and dedicated work.

The next phase of ONDRI (2018-2023) will build upon this foundation, supported by four pillars or aims, which are outlined in detail below. Please take the time to learn more about ONDRI’s role in advancing neurodegenerative disease research and improving diagnosis, prognosis and care outcomes for Ontarians living with neurodegenerative disease.

We look forward to engaging in this next phase of ONDRI with you. 

- Rick Swartz, Mario Masellis and Doug Munoz
ONDRI Leads

  Aim 1: Mining the Gold of ONDRI

THERE ARE TWO GOALS FOR AIM 1:
  • To identify the most useful markers of disease and dysfunction/function across diseases
  • To characterize markers of change over time to find predictors of decline (or stability). 

DATA RELEASED TO DATE

The ONDRI study platforms have been working hard to clean and curate the data, and their hard work is paying off! Almost all of the Core baseline tabular data has been released.  

To check on the release status of different datasets, please visit our newly enhanced Data Curation Status Dashboard within the Brain-CODE portal. 

GETTING PUBLISHED

We’re happy to announce that the ONDRI outlier paper has been accepted for publication in BMC Medical Research Methodology

Reminder: If you’re planning to submit a paper to a journal soon, please don’t forget the publication policy requirement that you first submit the paper to the publication committee, via its chair, for a final review and authorship check. Contact Mario.Masellis@sunnybrook.ca for this review. 

  Aim 2: ONDRI@Home

The purpose of Aim 2 is to develop scalable markers of disease and decline that are feasible for either clinical use, or for the development of clinical trials-ready cohorts.     

NEW INITIATIVES

ONDRI@HOME ReMiNDD PILOT     

The Remote Monitoring In NeuroDegenerative Diseases (ReMiNDD) Feasibility Study has been REB approved! Learn more about the study and its objectives.
 

  Aim 3: Validation Through Collaboration

The goal of Aim 3 is to validate markers developed in Aims 1-2 in other disease-based cohorts, and to explore their prevalence and predictive utility within established early disease and pre-symptomatic cohorts.
 
NEW GRANTS

Congratulations to Dr. Swardfager and several ONDRI Investigators who were awarded a 2019 Biomarkers Across Neurodegenerative Diseases (BAND 3) Program Grant, and a Michael J. Fox Foundation Target Advancement Program Grant! Learn more about their project.
 
NEW COLLABORATIONS

GEMINI

ONDRI is excited to collaborate with St. Michael’s Hospital’s General Medicine Inpatient Initiative (GEMINI), a “Big Data” research enterprise! Over the next year we will be using GEMINI data with the goal of training and testing an automated AI tool to identify delirium during hospitalization. Learn more.

  Aim 4: Health Services Research and KT

The purpose of Aim 4 is to catalyze health services research, system evaluation, knowledge translation and system interventions to improve the health and well-being of Ontarians with neurodegenerative disease. 

Aim 4 has identified a number of projects that are already in progress.

ONDRI POSTERS PRESENTED AT ROTMAN

This year, the Rotman Research Institute Conference focus was Aging & Brain Health. There, ONDRI presented six posters. Congrats to the scholars who participated!

FOUND@ONDRI

FOUND (Follow–Up Of Persons with Neurodegenerative Diseases) is a new initiative that aims to encourage ongoing follow-up and contact with ONDRI’s original cohort participants. Learn more about FOUND, including how to join.
 

   EVENTS

ONDRI ON-THE-ROAD

ONDRI is going on the road! We hope to visit each provincial site and meet with scientists and investigators in NDDs to share information about the direction of ONDRI, collect stories and examples of research initiatives, and engage in new collaborations and/or partnerships. More details

SCIENTIFIC RETREAT

May 27, 2019 at the Sheraton Gateway Hotel in Toronto International Airport Learn more & register now.
 
PATIENT AND COMMUNITY ADVISORY COMMITTEE (PCAC)

ONDRI recognizes the important role our PCAC plays in contributing to and challenging our research focus. We recently held a successful and informative Friends and Family Day. View photos and video from the event on our website, and stay tuned for future plans and opportunities for engagement.
 

  WE'RE LISTENING

Are you thinking about launching a new study? Are you interested in using ONDRI’s expertise in data curation and analyses pipelines? Do you want to collaborate with experts in data collection and curation? Do you need to bring specific expertise to your table, or do you want to have an informal chat about some ideas over a cup of coffee?

Please contact natalie.rashkovan@sunnybrook.ca to connect to the appropriate ONDRI players.
 
 
Ontario Neurodegenerative Disease Research Initiative
Sunnybrook Health Sciences Centre
2075 Bayview Ave, RM 448
Toronto, Ontario
M4N 3M5
Phone: 416-480-6100 ext. 6661
Email: info@ondri.ca


ONDRI 2075 Bayview Ave Toronto, On M4N3M5 Canada  
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