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Sod turn marks beginning of construction works at BIA Separations
We are delighted to announce that a six-million euro investment and a five-fold expansion of production has finally begun.
In our commitment to deliver products faster to companies and researchers producing life-saving therapeutics we are breaking ground on the first phase of BIA Separations’ expansion. In parallel, our R&D scientists are establishing second-generation production lines to provide even greater increase in production throughput. This increase will improve our flexibility to respond in times of critical demand, as we are currently seeing
Characterization of empty and full AAV capsids in complex samples by anion exchange HPLC with multiple monitors
Bioreactor cell supernatants or post lysis materials entering downstream purification are heterogeneous mixtures of empty, full, and misassembled AAV capsids mixed with HCPs, gDNA, chromatin complexes, and other contaminants. Monolith-based HPLC columns provide high resolution among these species but overlap of elution position among capsids and contaminants makes it impossible to estimate the relative content of full and empty capsids by UV absorbance.
Simultaneous monitoring with multiple detectors however enables quantitative insights that extend far beyond the limitations of UV absorbance. This poster demonstrates how the combination of fast high resolution separations with monoliths can be combined with multiple monitors to obtain much deeper characterization than traditional assays.
*The poster was prepared for the purposes of the ISBioTech 10th Spring Meeting conference, which was unfortunately cancelled.
CIMmultus™ Oligo dT affinity column based extraction of mRNA from IVT mixtures
The increasing demand for messenger RNA (mRNA) as a therapeutic product requires larger production scales and more efficient extraction techniques. In this poster, fast and efficient way to purify poly-adenylated mRNA using affinity chromatography on CIMmultus™ Oligo dT column is presented.
*The poster was prepared for the purposes of the ISBioTech 10th Spring Meeting conference, which was unfortunately cancelled
Development of coronavirus vaccines in full swing
The coronavirus situation has affected each and every one of us, but we believe that this experience will strengthen us and connect us even more. We would like to inform you that the supply of monolithic columns to clients developing the coronavirus vaccine has increased in recent weeks. We commit to ensuring a smooth delivery of our columns to everyone!
The remarkable monolithic technology is opening up boundless new possibilites for accelerated gene therapy development. Do you want to learn more about it?
Join us at 9th Monolith Summer Symposium and get an in-depth experience that will take your gene therapy projects to another level.
Register now
Early bird discount (15% off) prolonged till March 31, 2020.
MSS2020 and COVID-19. We are writing to inform you that there are no changes so far and the organization is proceeding as planned. We are aware of the fact that the situation with COVID-19 is very unpredictable and find ourselves obliged to find the right solution if things will get worse. Please keep in mind that in case the event is postponed due to the coronavirus situation, we will make sure that you are informed in a timely manner.
Copyright © 2020 BIA Separations, All rights reserved.

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